Description
CIALIS (TADALAFIL)
Cialis is most commonly used to treat erectile dysfunction and impotence, which is when a man struggles to maintain an erection or cannot get erect at all. It’s also sometimes prescribed for an enlarged prostate. Tadalafil is the active ingredient of Cialis. It improves blood flow to the penis so a man can get an erection for sexual activity. Depending on how your doctor prescribes the medication, you might take it as needed before sex or every day. If you take it as needed, the effects may last up to 36 hours.
Common use
Cialis is an effective, reversible, selective inhibitor of phosphodiesterase type 5 (PDE 5) specific to cyclic guanosine monophosphate (cGMP). When sexual stimulation causes the local release of nitric oxide, inhibition of PDE 5 by Cialis leads to an increase of cGMP levels in the cavernous body of the penis. It results in relaxation of arterial smooth muscles and blood flow to the tissues of the penis that causes erections. Cialis has no effect when sexual stimulation is absent. Cialis improves erection and lets achieve successful sexual intercourse. The drug acts for 36 hours. If sexual arousal is present the effect appears even after 16 minutes after taking the medication.
Mechanism of Action: Cialis works by inhibiting an enzyme called phosphodiesterase type 5 (PDE-5), which is responsible for breaking down a chemical called cGMP. cGMP is necessary for smooth muscle relaxation and increased blood flow to the penis, which leads to an erection when sexually stimulated.
Dosage and direction
The recommended dose of Cialis is 20 mg it should be taken at least 16 minutes before the sexual activity. The effect persists for 36 hours. Take Cialis once daily and do not exceed the recommended dose.
Precautions
It is preferable not to use Cialis with grapefruit juice, alcoholic beverages, or tobacco. If you smoke tobacco and take Cialis concomitantly this may lead to a condition called NAION (sudden optic nerve-related vision loss). Inform your doctor before taking Cialis if you have an abnormal penis, including a curved penis and birth defects of the penis, had coronary artery disease, arrhythmia, angina, heart attack or heart failure, hypo- or hypertension, bleeding, stomach ulcers, diabetes, hyperlipidemia (excess of lipids in the blood), sickle-cell anemia, liver or kidney failure in history.
Contraindications
Cialis is contraindicated in patients who are using any form of organic nitrate, either regularly and/ or intermittently as it is able to potentiate the hypotensive effect of nitrates.
Possible side effects
The most common side effects of Cialis are facial flushing (reddening), headaches, stomach upset, diarrhea, flu-like symptoms, and nausea. In rare cases, low blood pressure, blurred vision changes in color vision, and abnormal ejaculation may occur. Prolonged erections or priapism (painful erections lasting more than 6 hours) are also possible. If your erection is longer than 4 hours, seek for immediate medical help as it may permanently damage your penis. Aggravation of heart problems in patients with pre-existing heart disease using Cialis was reported.
Drug interactions
Co-administration with medications containing organic nitrates may cause severe hypotension which is dangerous in some cases. Avoid taking Cialis with medications such as Erythrityl Tetranitrate, Isosorbide Dinitrate, Isosorbide Mononitrate, Nitro-glycerine, Pentaerythritol Tetranitrate. Levels and toxicity of Cialis are increased by erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan) and ritonavir (Norvir). Inform your doctor if you are taking Atazanavir, Bunazosin, Clarithromycin, Doxazosin, Erythromycin, Indinavir, Itraconazole, Ketoconazole, Moxisylyte, Nefazodone, Nelfinavir, Phenoxybenzamine, Phentolamine, Prazosin, Saquinavir, Telithromycin, Terazosin, Trimazosin, Urapidil as your Cialis dose may require correction.
Missed dose
A missed dose is not supposed if Cialis is taken for treatment of erectile dysfunction as it is used when needed.
Overdose
Overdose of Cialis causes symptoms described as side effects. Seek immediate medical help if in your opinion you took too much of this medication.
Storage
Store at room temperature away from moisture, sunlight, kids, and pets in a tight container.
Disclaimer
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim the reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special, or other indirect damage due to any use of the information on this site and for consequences of self-treatment.
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